منابع مشابه
Distinct SoxB1 networks are required for naïve and primed pluripotency
Deletion of Sox2 from mouse embryonic stem cells (ESCs) causes trophectodermal differentiation. While this can be prevented by enforced expression of the related SOXB1 proteins, SOX1 or SOX3, the roles of SOXB1 proteins in epiblast stem cell (EpiSC) pluripotency are unknown. Here, we show that Sox2 can be deleted from EpiSCs with impunity. This is due to a shift in the balance of SoxB1 expressi...
متن کاملLIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.
The RNA-binding proteins LIN28A and LIN28B play critical roles in embryonic development, tumorigenesis, and pluripotency, but their exact functions are poorly understood. Here, we show that, like LIN28A, LIN28B can function effectively with NANOG, OCT4, and SOX2 in reprogramming to pluripotency and that reactivation of both endogenous LIN28A and LIN28B loci are required for maximal reprogrammin...
متن کاملCdh2 stabilizes FGFR1 and contributes to primed-state pluripotency in mouse epiblast stem cells
The cell adhesion molecule Cadherin 2 (Cdh2) plays important roles in somatic cell adhesion, proliferation and migration. Cdh2 is also highly expressed in mouse epiblast stem cells (mEpiSCs), but its function in these cells is unknown. To understand the function of Cdh2 in mEpiSCs, we compared the expression of pluripotency-related genes in mEpiSCs and mouse embryonic stem cells (mESCs) after e...
متن کاملUnderstanding stem cell states: naïve to primed pluripotency in rodents and humans
Preface The molecular mechanisms and signalling pathways that regulate the in vitro preservation of distinct pluripotent stem cell configurations, and their induction in somatic cells via direct reprogramming approaches, continue to constitute a highly exciting area of research. In this Review, we provide an integrative synthesis on recent discoveries related to isolating unique naïve and prime...
متن کاملCytoplasmic and Nuclear TAZ Exert Distinct Functions in Regulating Primed Pluripotency
Mouse epiblast stem cells (mEpiSCs) and human embryonic stem cells (hESCs) are primed pluripotent stem cells whose self-renewal can be maintained through cytoplasmic stabilization and retention of β-catenin. The underlying mechanism, however, remains largely unknown. Here, we show that cytoplasmic β-catenin interacts with and retains TAZ, a Hippo pathway effector, in the cytoplasm. Cytoplasmic ...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2011
ISSN: 1934-5909
DOI: 10.1016/j.stem.2011.02.009